Transgenerational inheritance of acquired epigenetic signatures at CpG islands in mice
Transgenerational inheritance of acquired epigenetic signatures at CpG islands in mice
Yuta Takahashi,M. Morales Valencia,13 作者,J. I. Izpisúa Belmonte
2023 · DOI: 10.1016/j.cell.2022.12.047
Cell · 引用数 112
TLDR
It is demonstrated that DNA methylation of promoter-associated CpG islands (CGIs) can be transmitted from parents to their offspring in mice, and these observations provide a concrete step toward demonstrating transgenerational epigenetic inheritance in mammals.