Suppression of the dorsomedial striatum impairs reversal learning in response to probabilistic uncertainty and disrupts corticostriatal function in mice
Suppression of the dorsomedial striatum impairs reversal learning in response to probabilistic uncertainty and disrupts corticostriatal function in mice
K. Conn,Joyosmita Das,2 作者,James P. Kesby
2025 · DOI: 10.1016/j.neuropharm.2025.110568
Neuropharmacology · 引用数 0
TLDR
It is suggested that inhibiting DMS function disrupts behavioural adaptation as well as corticostriatal co-activation, a mechanism that potentially contributes to the cognitive inflexibility observed in schizophrenia.