Inverted Urothelial Papilloma in a Young Woman: A Case Report and Review of Diagnostic Advances

Inverted urothelial papilloma (IUP) is an uncommon benign urothelial tumor characterized by an endophytic growth pattern. While it most commonly affects older male patients, we report the case of a young female patient with a bladder lesion located on the right lateral wall, an exceptionally rare clinical presentation in terms of age, sex, and tumor location. Such unusual presentations offer valuable learning opportunities and remind clinicians to consider rare benign entities in the differential diagnosis of bladder tumors. Accurate differentiation from urothelial carcinoma (UC) remains essential due to overlapping histological features. We emphasize the critical role of imaging, histopathology, and immunohistochemistry in reaching a definitive diagnosis, while highlighting the potential of emerging methods to enhance clinical decision-making. As radiomics and artificial intelligence (AI) continue to advance, they may significantly influence diagnostic approaches and future therapeutic strategies.